InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vps33a

Summary

InnateDB Protein

IDBP-199732.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vps33a

Protein Name

vacuolar protein sorting 33A (yeast)

Synonyms

3830421M04Rik; AI503300; AW048546; AW554476; bf;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031388

InnateDB Gene

IDBG-199730 (Vps33a)

Protein Structure

UniProt Annotation

Function

May play a role in vesicle-mediated protein trafficking to lysosomal compartments and in membrane docking/fusion reactions of late endosomes/lysosomes. {ECO:0000250}.

Subcellular Localization

Late endosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Lysosome membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Cytoplasmic, peripheral membrane protein associated with late endosomes/lysosomes. {ECO:0000250}.

Disease Associations

Note=Defects in Vps33a are the cause of the buff mutant which exhibits hypopigmentation in the coat and eyes, due to reduced size and number of melanosomes in their cells. In addition, mice are prone to prolonged bleeding, due to a platelet- storage pool defect.

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 11 interaction(s) predicted by orthology.

Predicted by orthology
Total	11 [view]

Gene Ontology

Molecular Function

Accession

GO Term

Biological Process

GO:0006904	vesicle docking involved in exocytosis
GO:0015031	protein transport
GO:0016192	vesicle-mediated transport
GO:0030220	platelet formation
GO:0043473	pigmentation
GO:0048070	regulation of developmental pigmentation