InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pak1

Summary

InnateDB Protein

IDBP-199976.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pak1

Protein Name

p21 protein (Cdc42/Rac)-activated kinase 1

Synonyms

AW045634; PAK-1; Paka;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000033040

InnateDB Gene

IDBG-199974 (Pak1)

Protein Structure

UniProt Annotation

Function

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 26 experimentally validated interaction(s) in this database.
They are also associated with 74 interaction(s) predicted by orthology.

Experimentally validated
Total	26 [view]
Protein-Protein	25 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	1 [view]
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	74 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004702	receptor signaling protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005515	protein binding
GO:0005518	collagen binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0019901	protein kinase binding

Biological Process

GO:0001666	response to hypoxia
GO:0001934	positive regulation of protein phosphorylation
GO:0006468	protein phosphorylation
GO:0007015	actin filament organization
GO:0007409	axonogenesis
GO:0007528	neuromuscular junction development
GO:0010033	response to organic substance
GO:0016358	dendrite development
GO:0023014	signal transduction by phosphorylation
GO:0030036	actin cytoskeleton organization
GO:0031532	actin cytoskeleton reorganization
GO:0032869	cellular response to insulin stimulus
GO:0032956	regulation of actin cytoskeleton organization
GO:0033138	positive regulation of peptidyl-serine phosphorylation
GO:0033148	positive regulation of intracellular estrogen receptor signaling pathway
GO:0035556	intracellular signal transduction
GO:0042060	wound healing
GO:0043113	receptor clustering
GO:0043507	positive regulation of JUN kinase activity
GO:0046777	protein autophosphorylation
GO:0048754	branching morphogenesis of an epithelial tube
GO:0048812	neuron projection morphogenesis
GO:0051496	positive regulation of stress fiber assembly
GO:0060244	negative regulation of cell proliferation involved in contact inhibition

Cellular Component

GO:0001726	ruffle
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0005911	cell-cell junction
GO:0005925	focal adhesion
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0030018	Z disc
GO:0030424	axon
GO:0030425	dendrite
GO:0030426	growth cone
GO:0031965	nuclear membrane
GO:0043234	protein complex

Protein Structure and Domains

PDB ID

MGI:1339975

InterPro

IPR000095 CRIB domain
IPR000719 Protein kinase domain
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR011026 Wiscott-Aldrich syndrome protein, C-terminal
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00786
PF00069
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00285
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt