InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: PAN3

Summary

InnateDB Protein

IDBP-20001.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

PAN3

Protein Name

PAN3 poly(A) specific ribonuclease subunit homolog (S. cerevisiae)

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000370345

InnateDB Gene

IDBG-19995 (PAN3)

Protein Structure

UniProt Annotation

Function

Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein (PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with PABP and to miRNA targets via its interaction with GW182 family proteins. {ECO:0000255HAMAP-Rule:MF_03181, ECO:0000269PubMed:14583602, ECO:0000269PubMed:23932717}.

Subcellular Localization

Cytoplasm, P-body {ECO:0000255HAMAP- Rule:MF_03181, ECO:0000269PubMed:14583602, ECO:0000269PubMed:18625844}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 8 experimentally validated interaction(s) in this database.

Experimentally validated
Total	8 [view]
Protein-Protein	8 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004535	poly(A)-specific ribonuclease activity
GO:0004672	protein kinase activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0016772	transferase activity, transferring phosphorus-containing groups
GO:0046872	metal ion binding

Biological Process

GO:0000288	nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
GO:0000289	nuclear-transcribed mRNA poly(A) tail shortening
GO:0000290	deadenylation-dependent decapping of nuclear-transcribed mRNA
GO:0006468	protein phosphorylation
GO:0006605	protein targeting
GO:0010467	gene expression
GO:0010606	positive regulation of cytoplasmic mRNA processing body assembly
GO:0016070	RNA metabolic process
GO:0016071	mRNA metabolic process
GO:0090503	RNA phosphodiester bond hydrolysis, exonucleolytic