InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Galnt2

Summary

InnateDB Protein

IDBP-200015.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Galnt2

Protein Name

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000034458

InnateDB Gene

IDBG-487552 (Galnt2)

Protein Structure

UniProt Annotation

Function

Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has a broad spectrum of substrates for peptides such as EA2, Muc5AC, Muc1a, Muc1b. Probably involved in O-linked glycosylation of the immunoglobulin A1 (IgA1) hinge region (By similarity). {ECO:0000250}.

Subcellular Localization

Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Secreted. Note=Resides preferentially in the trans and medial parts of the Golgi stack. A secreted form also exists.

Disease Associations

Tissue Specificity

Widely expressed at high level. {ECO:0000269PubMed:12651884}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004653	polypeptide N-acetylgalactosaminyltransferase activity
GO:0005509	calcium ion binding
GO:0005529	sugar binding
GO:0016740	transferase activity
GO:0016757	transferase activity, transferring glycosyl groups
GO:0030145	manganese ion binding

Biological Process

GO:0006493

protein O-linked glycosylation

Cellular Component

GO:0005576	extracellular region
GO:0005794	Golgi apparatus
GO:0005796	Golgi lumen
GO:0016020	membrane
GO:0016021	integral component of membrane
GO:0032580	Golgi cisterna membrane