InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Map4k3

Summary

InnateDB Protein

IDBP-200028.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Map4k3

Protein Name

mitogen-activated protein kinase kinase kinase kinase 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025089

InnateDB Gene

IDBG-200026 (Map4k3)

Protein Structure

UniProt Annotation

Function

May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	10 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0004674	protein serine/threonine kinase activity
GO:0004713	protein tyrosine kinase activity
GO:0005083	small GTPase regulator activity
GO:0005515	protein binding
GO:0005524	ATP binding
GO:0008349	MAP kinase kinase kinase kinase activity
GO:0016772	transferase activity, transferring phosphorus-containing groups

Biological Process

GO:0000165	MAPK cascade
GO:0000185	activation of MAPKKK activity
GO:0006468	protein phosphorylation
GO:0009411	response to UV
GO:0035556	intracellular signal transduction

Cellular Component

GO:0005737

cytoplasm

Protein Structure and Domains

PDB ID

MGI:2154405

InterPro

IPR000719 Protein kinase domain
IPR001180 Citron-like
IPR001245 Serine-threonine/tyrosine-protein kinase catalytic domain
IPR002290 Serine/threonine- /dual specificity protein kinase, catalytic domain
IPR011009 Protein kinase-like domain
IPR020635 Tyrosine-protein kinase, catalytic domain

PFAM

PF00069
PF00780
PF07714

PRINTS

PR00109

PIRSF

SMART

SM00036
SM00220
SM00219

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt