InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rilp

Summary

InnateDB Protein

IDBP-200090.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rilp

Protein Name

Rab interacting lysosomal protein

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000037238

InnateDB Gene

IDBG-200088 (Rilp)

Protein Structure

UniProt Annotation

Function

Rab effector playing a role in late endocytic transport to degradative compartments. Involved in the regulation of lysosomal morphology and distribution. Induces recruitment of dynein-dynactin motor complexes to Rab7A-containing late endosome and lysosome compartments. Promotes centripetal migration of phagosomes and the fusion of phagosomes with the late endosomes and lysosomes (By similarity). {ECO:0000250}.

Subcellular Localization

Endomembrane system {ECO:0000250}. Late endosome membrane {ECO:0000250}. Lysosome membrane {ECO:0000250}. Cytoplasmic vesicle, phagosome membrane {ECO:0000250}. Note=Associated with late endosomal, lysosomal and phagosomal membranes. The interaction with RAB7A is necessary for its recruitment to phagosomes (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding

Biological Process

GO:0008333	endosome to lysosome transport
GO:0015031	protein transport

Cellular Component

GO:0005739	mitochondrion
GO:0005764	lysosome
GO:0005765	lysosomal membrane
GO:0030670	phagocytic vesicle membrane
GO:0031902	late endosome membrane
GO:0043234	protein complex