InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Scarf1

Summary

InnateDB Protein

IDBP-200121.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Scarf1

Protein Name

scavenger receptor class F, member 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044248

InnateDB Gene

IDBG-200119 (Scarf1)

Protein Structure

UniProt Annotation

Function

Mediates the binding and degradation of acetylated low density lipoprotein (Ac-LDL). Mediates heterophilic interactions, suggesting a function as adhesion protein (By similarity). Plays a role in the regulation of neurite-like outgrowth. {ECO:0000250, ECO:0000269PubMed:15247299}.

Subcellular Localization

Membrane {ECO:0000305}; Single-pass type I membrane protein {ECO:0000305}.

Disease Associations

Tissue Specificity

Expressed weakly in brain, spinal cord and dorsal root ganglions. {ECO:0000269PubMed:15247299}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005044	scavenger receptor activity
GO:0005515	protein binding
GO:0030169	low-density lipoprotein particle binding

Biological Process

GO:0006898	receptor-mediated endocytosis
GO:0007155	cell adhesion
GO:0010976	positive regulation of neuron projection development
GO:0016322	neuron remodeling
GO:0016358	dendrite development
GO:0048680	positive regulation of axon regeneration