InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mga

Summary

InnateDB Protein

IDBP-200143.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mga

Protein Name

MAX gene associated

Synonyms

AV312082; C130042M01Rik; C80739; D030062C11Rik; Mad5;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000043795

InnateDB Gene

IDBG-200139 (Mga)

Protein Structure

UniProt Annotation

Function

Functions as a dual-specificity transcription factor, regulating the expression of both MAX-network and T-box family target genes. Functions as a repressor or an activator. Binds to 5'-AATTTCACACCTAGGTGTGAAATT-3' core sequence and seems to regulate MYC-MAX target genes. Suppresses transcriptional activation by MYC and inhibits MYC-dependent cell transformation. Function activated by heterodimerization with MAX. This heterodimerization serves the dual function of both generating an E-box-binding heterodimer and simultaneously blocking interaction of a corepressor.

Subcellular Localization

Nucleus {ECO:0000305}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 18 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	18 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0046983	protein dimerization activity