Version 5.4
Mus musculus Protein: Agt
Summary
InnateDB Protein IDBP-200171.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Agt
Protein Name angiotensinogen (serpin peptidase inhibitor, clade A, member 8)
Synonyms AI265500; AngI; AngII; Aogen; Serpina8;
Species Mus musculus
Ensembl Protein ENSMUSP00000066488
InnateDB Gene IDBG-200169 (Agt)
Protein Structure
UniProt Annotation
Function
Subcellular Localization
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0004867 serine-type endopeptidase inhibitor activity
GO:0005179 hormone activity
GO:0005515 protein binding
GO:0010698 acetyltransferase activator activity
GO:0031701 angiotensin receptor binding
GO:0031702 type 1 angiotensin receptor binding
GO:0031703 type 2 angiotensin receptor binding
Biological Process
GO:0001543 ovarian follicle rupture
GO:0001568 blood vessel development
GO:0001658 branching involved in ureteric bud morphogenesis
GO:0001822 kidney development
GO:0001991 regulation of systemic arterial blood pressure by circulatory renin-angiotensin
GO:0001998 angiotensin mediated vasoconstriction involved in regulation of systemic arterial blood pressure
GO:0001999 renal response to blood flow involved in circulatory renin-angiotensin regulation of systemic arterial blood pressure
GO:0002018 renin-angiotensin regulation of aldosterone production
GO:0002019 regulation of renal output by angiotensin
GO:0002035 brain renin-angiotensin system
GO:0003014 renal system process
GO:0003051 angiotensin-mediated drinking behavior
GO:0003331 positive regulation of extracellular matrix constituent secretion
GO:0006883 cellular sodium ion homeostasis
GO:0007160 cell-matrix adhesion
GO:0007166 cell surface receptor signaling pathway
GO:0007186 G-protein coupled receptor signaling pathway
GO:0007202 activation of phospholipase C activity
GO:0007250 activation of NF-kappaB-inducing kinase activity
GO:0007565 female pregnancy
GO:0007568 aging
GO:0007588 excretion
GO:0008065 establishment of blood-nerve barrier
GO:0008217 regulation of blood pressure
GO:0008284 positive regulation of cell proliferation
GO:0008285 negative regulation of cell proliferation
GO:0009409 response to cold
GO:0009651 response to salt stress
GO:0010468 regulation of gene expression
GO:0010535 positive regulation of activation of JAK2 kinase activity
GO:0010595 positive regulation of endothelial cell migration
GO:0010613 positive regulation of cardiac muscle hypertrophy
GO:0010628 positive regulation of gene expression
GO:0010873 positive regulation of cholesterol esterification
GO:0010951 negative regulation of endopeptidase activity
GO:0014061 regulation of norepinephrine secretion
GO:0014068 positive regulation of phosphatidylinositol 3-kinase signaling
GO:0014824 artery smooth muscle contraction
GO:0014873 response to muscle activity involved in regulation of muscle adaptation
GO:0016525 negative regulation of angiogenesis
GO:0030162 regulation of proteolysis
GO:0030198 extracellular matrix organization
GO:0030308 negative regulation of cell growth
GO:0030432 peristalsis
GO:0032270 positive regulation of cellular protein metabolic process
GO:0032930 positive regulation of superoxide anion generation
GO:0034104 negative regulation of tissue remodeling
GO:0035411 catenin import into nucleus
GO:0035813 regulation of renal sodium excretion
GO:0035815 positive regulation of renal sodium excretion
GO:0040018 positive regulation of multicellular organism growth
GO:0042310 vasoconstriction
GO:0042311 vasodilation
GO:0042445 hormone metabolic process
GO:0042756 drinking behavior
GO:0042981 regulation of apoptotic process
GO:0043085 positive regulation of catalytic activity
GO:0043410 positive regulation of MAPK cascade
GO:0043524 negative regulation of neuron apoptotic process
GO:0045429 positive regulation of nitric oxide biosynthetic process
GO:0045723 positive regulation of fatty acid biosynthetic process
GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway
GO:0045777 positive regulation of blood pressure
GO:0045893 positive regulation of transcription, DNA-templated
GO:0045909 positive regulation of vasodilation
GO:0046622 positive regulation of organ growth
GO:0048143 astrocyte activation
GO:0048144 fibroblast proliferation
GO:0048146 positive regulation of fibroblast proliferation
GO:0048169 regulation of long-term neuronal synaptic plasticity
GO:0048659 smooth muscle cell proliferation
GO:0050663 cytokine secretion
GO:0050727 regulation of inflammatory response
GO:0050731 positive regulation of peptidyl-tyrosine phosphorylation
GO:0051145 smooth muscle cell differentiation
GO:0051387 negative regulation of neurotrophin TRK receptor signaling pathway
GO:0051403 stress-activated MAPK cascade
GO:0051924 regulation of calcium ion transport
GO:0051969 regulation of transmission of nerve impulse
GO:0061049 cell growth involved in cardiac muscle cell development
GO:0061098 positive regulation of protein tyrosine kinase activity
GO:0070371 ERK1 and ERK2 cascade
GO:0070471 uterine smooth muscle contraction
GO:0071260 cellular response to mechanical stimulus
GO:0090190 positive regulation of branching involved in ureteric bud morphogenesis
GO:2001238 positive regulation of extrinsic apoptotic signaling pathway
Cellular Component
GO:0005615 extracellular space
GO:0005737 cytoplasm
GO:0070062 extracellular vesicular exosome
GO:0072562 blood microparticle
Protein Structure and Domains
PDB ID MGI:87963
InterPro IPR000227 Angiotensinogen
IPR023796 Serpin domain
PFAM PF00079
PRINTS PR00654
PIRSF
SMART SM00093
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt
PhosphoSite PhosphoSite-
TrEMBL Q3UTR7
UniProt Splice Variant
Entrez Gene 11606
UniGene Mm.301626
RefSeq NP_031454
MGI ID
MGI Symbol Agt
OMIM
CCDS CCDS40513
HPRD
IMGT
EMBL AC126930 AK139179
GenPept BAE23913

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca