InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Capzb

Summary

InnateDB Protein

IDBP-200257.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Capzb

Protein Name

capping protein (actin filament) muscle Z-line, beta

Synonyms

1700120C01Rik; AI325129; Cappb1; CPB1; CPB2; CPbeat2; CPbeta1; CPbeta2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000099565

InnateDB Gene

IDBG-200253 (Capzb)

Protein Structure

UniProt Annotation

Function

F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. Isoform 3 may play a role in spermatogenesis. Alternatively, may play a role in later maturation steps such as capacitation and fertilization which involve changes of membrane domains. Plays a role in the regulation of cell morphology and cytoskeletal organization (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton {ECO:0000250}.Isoform 1: Cytoplasm, myofibril, sarcomere, Z line {ECO:0000250}. Cytoplasm, myofibril, sarcomere {ECO:0000250}. Note=In cardiac muscle, isoform 1 is located at Z- disks of sarcomeres while isoform 2 is enriched at intercalated disks. {ECO:0000250}.Isoform 3: Cytoplasm, cytoskeleton, perinuclear theca, calyx {ECO:0000250}. Note=Isoform 3 is located to sperm head cytoskeletal structure tightly associated to the nucleus (By similarity). Isoform 3 colocalizes with the alpha subunit in testicular sperm and to the acrosome in elongating and condensing spermatids. {ECO:0000250}.

Disease Associations

Tissue Specificity

Isoform 3 is testis-specific and is present in round spermatids, but not in pachytene spermatocytes or Sertoli cells. {ECO:0000269PubMed:19341723}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 18 experimentally validated interaction(s) in this database.
They are also associated with 38 interaction(s) predicted by orthology.

Experimentally validated
Total	18 [view]
Protein-Protein	18 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	38 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003779	actin binding
GO:0005515	protein binding
GO:0048487	beta-tubulin binding
GO:0051015	actin filament binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0022604	regulation of cell morphogenesis
GO:0030030	cell projection organization
GO:0030032	lamellipodium assembly
GO:0030036	actin cytoskeleton organization
GO:0031115	negative regulation of microtubule polymerization
GO:0031175	neuron projection development
GO:0048747	muscle fiber development
GO:0051016	barbed-end actin filament capping
GO:0090036	regulation of protein kinase C signaling

Cellular Component

GO:0001669	acrosomal vesicle
GO:0008290	F-actin capping protein complex
GO:0014704	intercalated disc
GO:0016020	membrane
GO:0030018	Z disc
GO:0030027	lamellipodium
GO:0030863	cortical cytoskeleton
GO:0033150	cytoskeletal calyx
GO:0071203	WASH complex