InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arl6ip4

Summary

InnateDB Protein

IDBP-200315.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arl6ip4

Protein Name

ADP-ribosylation factor-like 6 interacting protein 4

Synonyms

AA408210; AA408365; Aip-4; Srp25;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031351

InnateDB Gene

IDBG-200313 (Arl6ip4)

Protein Structure

UniProt Annotation

Function

Involved in modulating alternative pre-mRNA splicing with either 5' distal site activation or preferential use of 3' proximal site. {ECO:0000250}.

Subcellular Localization

Nucleus, nucleolus {ECO:0000250}. Nucleus speckle {ECO:0000250}.

Disease Associations

Tissue Specificity

Widely expressed. Expressed at high level in testis and thymus. {ECO:0000269PubMed:10708573}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	8 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0044822	poly(A) RNA binding

Biological Process

GO:0006397	mRNA processing
GO:0008380	RNA splicing

Cellular Component

GO:0005730	nucleolus
GO:0016607	nuclear speck

Protein Structure and Domains

PDB ID

MGI:1929500

InterPro

IPR019532 Nuclear RNA-splicing-associated protein, SR-25

PFAM

PF10500

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JM93

PhosphoSite

PhosphoSite-Q9JM93

TrEMBL

D3Z668

UniProt Splice Variant

Entrez Gene

65105

UniGene

Mm.489547

RefSeq

NP_653092

MGI ID

MGI Symbol

Arl6ip4

OMIM

CCDS

CCDS19673

HPRD

IMGT

EMBL

AB035383 AC113474 AF133911 AK133934 BC063748

GenPept

AAD33049 AAH63748 BAA94743 BAE21935