InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Arih2

Summary

InnateDB Protein

IDBP-200344.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Arih2

Protein Name

ariadne homolog 2 (Drosophila)

Synonyms

AI843547; ARI2; TRIAD1; UIP48;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000013338

InnateDB Gene

IDBG-200342 (Arih2)

Protein Structure

UniProt Annotation

Function

E3 ubiquitin-protein ligase mediating 'Lys-48'-and 'Lys- 63'-linked polyubiquitination and subsequent proteasomal degradation of modified proteins. May play a role in myelopoiesis (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus. Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 6 experimentally validated interaction(s) in this database.
They are also associated with 42 interaction(s) predicted by orthology.

Experimentally validated
Total	6 [view]
Protein-Protein	6 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	42 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003676	nucleic acid binding
GO:0004842	ubiquitin-protein transferase activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity

Biological Process

GO:0000209	protein polyubiquitination
GO:0006511	ubiquitin-dependent protein catabolic process
GO:0042787	protein ubiquitination involved in ubiquitin-dependent protein catabolic process
GO:0048588	developmental cell growth
GO:0070534	protein K63-linked ubiquitination
GO:0070936	protein K48-linked ubiquitination
GO:0071425	hematopoietic stem cell proliferation