InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mta3

Summary

InnateDB Protein

IDBP-200355.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mta3

Protein Name

metastasis associated 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000068931

InnateDB Gene

IDBG-200353 (Mta3)

Protein Structure

UniProt Annotation

Function

Plays a role in maintenance of the normal epithelial architecture through the repression of SNAI1 transcription in a histone deacetylase-dependent manner, and thus the regulation of E-cadherin levels. Contributes to transcriptional repression by BCL6 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000255PROSITE- ProRule:PRU00512, ECO:0000255PROSITE-ProRule:PRU00624, ECO:0000269PubMed:11483358}. Cytoplasm {ECO:0000269PubMed:11483358}.

Disease Associations

Tissue Specificity

Expressed in heart, brain, spleen, lung, liver and kidney.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 13 experimentally validated interaction(s) in this database.
They are also associated with 28 interaction(s) predicted by orthology.

Experimentally validated
Total	13 [view]
Protein-Protein	13 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	28 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0006355	regulation of transcription, DNA-templated
GO:0008284	positive regulation of cell proliferation
GO:0010971	positive regulation of G2/M transition of mitotic cell cycle

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0008278	cohesin complex
GO:0016581	NuRD complex
GO:0043231	intracellular membrane-bounded organelle

Protein Structure and Domains

PDB ID

MGI:2151172

InterPro

IPR000679 Zinc finger, GATA-type
IPR000949 ELM2 domain
IPR001005 SANT/Myb domain
IPR001025 Bromo adjacent homology (BAH) domain
IPR009057 Homeodomain-like

PFAM

PF00320
PF01448
PF00249
PF01426

PRINTS

PR00619

PIRSF

SMART

SM00401
SM00717
SM00439

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt