Version 5.4
Mus musculus Protein: 2210018M11Rik
Summary
InnateDB Protein IDBP-200423.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol 2210018M11Rik
Protein Name RIKEN cDNA 2210018M11 gene
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000038216
InnateDB Gene IDBG-200421 (2210018M11Rik)
Protein Structure
UniProt Annotation
Function Regulator which is able to repress transcription, possibly via its interaction with a multiprotein chromatin remodeling complex that modifies the chromatin. Its interaction with BRCA2 suggests that it may play a central role in the DNA repair function of BRCA2 (By similarity). As part of a H3-specific methyltransferase complex may mediate ligand-dependent transcriptional activation by nuclear hormone receptors (By similarity). {ECO:0000250}.
Subcellular Localization Nucleus {ECO:0000269PubMed:14651845}. Note=Localizes to DNA damage markers in irradiated cells, suggesting that it participates in DNA repair process.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
GO:0042803 protein homodimerization activity
Biological Process
GO:0006281 DNA repair
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
GO:0016568 chromatin modification
Cellular Component
GO:0005634 nucleus
Protein Structure and Domains
PDB ID MGI:1924203
InterPro IPR005491 EMSY N-terminal
PFAM PF03735
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BMB0
PhosphoSite PhosphoSite-Q8BMB0
TrEMBL
UniProt Splice Variant
Entrez Gene 233545
UniGene
RefSeq NP_758484
MGI ID
MGI Symbol 2210018M11Rik
OMIM
CCDS CCDS40028
HPRD
IMGT
EMBL AK032985 BC020109 BC039956 BC089304
GenPept AAH20109 AAH89304 BAC28113

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca