InnateDB Protein
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IDBP-200490.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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St6galnac3
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Protein Name
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ST6 (alpha-N-acetyl-neuraminyl-2,3-beta-galactosyl-1,3)-N-acetylgalactosaminide alpha-2,6-sialyltransferase 3
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Synonyms
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Siat7c;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000068598
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InnateDB Gene
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IDBG-200488 (St6galnac3)
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Protein Structure
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Function |
Involved in the biosynthesis of ganglioside GD1A from GM1B. Transfers CMP-NeuAc with an alpha-2,6-linkage to GalNAc residue on NeuAc-alpha-2,3-Gal-beta-1,3-GalNAc of glycoproteins and glycolipids. ST6GalNAcIII prefers glycolipids to glycoproteins. {ECO:0000269PubMed:10207017}.
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Subcellular Localization |
Golgi apparatus membrane {ECO:0000305}; Single-pass type II membrane protein {ECO:0000305}.
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Disease Associations |
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Tissue Specificity |
High expression in brain, lung and heart and to a lesser extent in kidney, mammary gland, spleen, testis and thymus. {ECO:0000269PubMed:10207017}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
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Molecular Function |
Accession |
GO Term |
GO:0008373
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sialyltransferase activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1341828
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InterPro |
IPR001675
Glycosyl transferase, family 29
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PFAM |
PF00777
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9WUV2
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PhosphoSite |
PhosphoSite-
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TrEMBL |
Q544M3
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UniProt Splice Variant |
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Entrez Gene |
20447
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UniGene |
Mm.440929
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RefSeq |
NP_035502
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MGI ID |
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MGI Symbol |
St6galnac3
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OMIM |
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CCDS |
CCDS38677
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HPRD |
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IMGT |
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EMBL |
AK034804
BC058387
BC131987
BC132317
CH466532
Y11342
Y11343
Y11344
Y11345
Y11346
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GenPept |
AAH58387
AAI31988
AAI32318
BAC28836
CAA72181
CAB95031
EDL11908
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