InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Tsnax

Summary

InnateDB Protein

IDBP-200548.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Tsnax

Protein Name

translin-associated factor X

Synonyms

R74833; Trax;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000075290

InnateDB Gene

IDBG-200546 (Tsnax)

Protein Structure

UniProt Annotation

Function

Acts in combination with TSN as an endonuclease involved in the activation of the RNA-induced silencing complex (RISC). Possible role in spermatogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, perinuclear region {ECO:0000250}. Golgi apparatus {ECO:0000269PubMed:15314092}. Nucleus {ECO:0000250}. Note=Expressed in the cytoplasm in the presence of TSN (By similarity). Accumulate in the Golgi complex of mid-late pachytene spermatocytes. {ECO:0000250}.

Disease Associations

Tissue Specificity

Detected in heart, brain, lung, liver, kidney and testis. {ECO:0000269PubMed:10790540}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 19 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	19 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003697	single-stranded DNA binding
GO:0005515	protein binding
GO:0031687	A2A adenosine receptor binding
GO:0032403	protein complex binding
GO:0043565	sequence-specific DNA binding
GO:0046872	metal ion binding

Biological Process

GO:0007275	multicellular organismal development
GO:0007283	spermatogenesis
GO:0030154	cell differentiation

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005794	Golgi apparatus
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1855672

InterPro

IPR002848 Translin

PFAM

PF01997

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9QZE7

PhosphoSite

PhosphoSite-Q9QZE7

TrEMBL

UniProt Splice Variant

Entrez Gene

53424

UniGene

RefSeq

NP_058605

MGI ID

MGI Symbol

Tsnax

OMIM

CCDS

CCDS22778

HPRD

IMGT

EMBL

AF187040 AK030407 AK146339 BC004611

GenPept

AAF05529 AAH04611 BAC26948 BAE27093