InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mogat2

Summary

InnateDB Protein

IDBP-200605.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mogat2

Protein Name

monoacylglycerol O-acyltransferase 2

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064041

InnateDB Gene

IDBG-200603 (Mogat2)

Protein Structure

UniProt Annotation

Function

Catalyzes the formation of diacylglycerol from 2- monoacylglycerol and fatty acyl-CoA. Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0. Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. May play a role in diet-induced obesity. {ECO:0000269PubMed:12576479, ECO:0000269PubMed:12730219, ECO:0000269PubMed:14966132}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:14966132}; Multi-pass membrane protein {ECO:0000269PubMed:14966132}.

Disease Associations

Tissue Specificity

Mainly expressed in small intestine. Detected in the small intestine in a proximal-to-distal gradient that correlated with fat absorption pattern. Present not only in the villi, but also in the crypt regions of the small intestine, which suggests that expression occurs prior to the maturation of enterocytes. Not detectable in other sections of the digestive tract, including stomach, cecum, colon and rectum, or other tissues such as kidney, liver and adipocytes (at protein level). Also detected in kidney, adipose and stomach. Expressed at very low level in liver, skeletal muscle and spleen. Not expressed in brain, heart, lung, skin, testis and thymus. {ECO:0000269PubMed:12576479, ECO:0000269PubMed:12621063, ECO:0000269PubMed:14966132}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003846	2-acylglycerol O-acyltransferase activity
GO:0016407	acetyltransferase activity
GO:0016747	transferase activity, transferring acyl groups other than amino-acyl groups

Biological Process

GO:0006071	glycerol metabolic process
GO:0006629	lipid metabolic process
GO:0006651	diacylglycerol biosynthetic process
GO:0019432	triglyceride biosynthetic process
GO:0046462	monoacylglycerol metabolic process
GO:0050892	intestinal absorption