InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Mtap6

Summary

InnateDB Protein

IDBP-200614.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Mtap6

Protein Name

microtubule-associated protein 6

Synonyms

2810411E12Rik; Map-6; Mtap6; STOP;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000064787

InnateDB Gene

IDBG-200612 (Mtap6)

Protein Structure

UniProt Annotation

Function

Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B. {ECO:0000269PubMed:9600916}.

Subcellular Localization

Cytoplasm, cytoskeleton. Golgi apparatus. Note=Isoform 1 and isoform 2 associate with axonal microtubules in neurons. Isoform 3 associates with microtubules in fibroblasts.

Disease Associations

Tissue Specificity

Isoform 1 is specifically expressed in adult brain. Isoform 2 is predominantly expressed in embryonic brain; expression persists at low levels in the adult brain. Isoform 3 is expressed at high levels in lung and at lower levels in testis, heart, muscle and kidney (at protein level). Oligodendrocytes express a major isoform of 89 kDa (O-STOP). Astrocytes also express an isoform of 60 kDa (A-STOP). {ECO:0000269PubMed:12782132, ECO:0000269PubMed:15389836}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Experimentally validated
Total	7 [view]
Protein-Protein	7 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0005516	calmodulin binding
GO:0008017	microtubule binding

Biological Process

GO:0000226	microtubule cytoskeleton organization
GO:0006810	transport
GO:0032418	lysosome localization
GO:0048813	dendrite morphogenesis

Cellular Component

GO:0005794	Golgi apparatus
GO:0005874	microtubule
GO:0048471	perinuclear region of cytoplasm

Protein Structure and Domains

PDB ID

MGI:1201690

InterPro

IPR024963 MAP6/FAM154

PFAM

PF05217

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q7TSJ2

PhosphoSite

PhosphoSite-Q7TSJ2

TrEMBL

UniProt Splice Variant

Entrez Gene

17760

UniGene

Mm.439460

RefSeq

NP_034967

MGI ID

MGI Symbol

Map6

OMIM

CCDS

CCDS21479

HPRD

IMGT

EMBL

BC053039 Y14754 Y14755 Y14756 Y16008 Y16032

GenPept

AAH53039 CAA75049 CAA75930 CAA75989