Version 5.4
Homo sapiens Protein: EMB
Summary
InnateDB Protein IDBP-20062.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol EMB
Protein Name embigin
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000302289
InnateDB Gene IDBG-20060 (EMB)
Protein Structure
UniProt Annotation
Function Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1 and SLC16A7 to the cell membrane (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane {ECO:0000250}; Single-pass type I membrane protein {ECO:0000250}. Cell junction, synapse {ECO:0000250}. Note=Localizes to the neuromuscular junctions. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0007155 cell adhesion
GO:0035879 plasma membrane lactate transport
Cellular Component
GO:0005887 integral component of plasma membrane
GO:0030054 cell junction
GO:0045202 synapse
Protein Structure and Domains
PDB ID
InterPro IPR003599 Immunoglobulin subtype
IPR007110 Immunoglobulin-like domain
IPR013098 Immunoglobulin I-set
PFAM PF07679
PRINTS
PIRSF
SMART SM00409
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q6PCB8
PhosphoSite PhosphoSite-Q6PCB8
TrEMBL B7Z902
UniProt Splice Variant
Entrez Gene 133418
UniGene Hs.697682
RefSeq NP_940851
HUGO HGNC:30465
OMIM 615669
CCDS CCDS3953
HPRD 13271
IMGT
EMBL AC035145 AC091833 AK300860 AK304226 BC059398 CH471123
GenPept AAH59398 BAH13359 BAH14138 EAW54853 EAW54854

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca