InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Dync2li1

Summary

InnateDB Protein

IDBP-200638.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Dync2li1

Protein Name

dynein cytoplasmic 2 light intermediate chain 1

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000025101

InnateDB Gene

IDBG-200636 (Dync2li1)

Protein Structure

UniProt Annotation

Function

May function as a motor for intraflagellar retrograde transport. Functions in cilia biogenesis (By similarity). {ECO:0000250}.

Subcellular Localization

Cytoplasm, cytoskeleton, cilium axoneme {ECO:0000269PubMed:12802074}. Cytoplasm {ECO:0000269PubMed:12802074}. Note=Localizes to the apical cytoplasm.

Disease Associations

Tissue Specificity

Specifically expressed by ciliated cells in brain, lung, spleen, testis and kidney (at protein level). Enriched in the ependymal layer lining the lateral ventricles (at protein level). {ECO:0000269PubMed:11907264, ECO:0000269PubMed:12432068, ECO:0000269PubMed:12802074, ECO:0000269PubMed:15371312}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0003774	motor activity
GO:0005515	protein binding

Biological Process

GO:0007368	determination of left/right symmetry
GO:0008152	metabolic process
GO:0042384	cilium assembly

Cellular Component

GO:0005874	microtubule
GO:0005930	axoneme
GO:0030286	dynein complex
GO:0030990	intraciliary transport particle
GO:0031512	motile primary cilium
GO:0045177	apical part of cell