InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rilpl1

Summary

InnateDB Protein

IDBP-200713.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rilpl1

Protein Name

Rab interacting lysosomal protein-like 1

Synonyms

2900002H16Rik; 6330559I19Rik; GOSPEL;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000050014

InnateDB Gene

IDBG-200711 (Rilpl1)

Protein Structure

UniProt Annotation

Function

Neuroprotective protein, which acts by sequestring GAPDH in the cytosol and prevent the apoptotic function of GAPDH in the nucleus. Competes with SIAH1 for binding GAPDH. Does not regulate lysosomal morphology and distribution (By similarity). Plays a role in the regulation of cell shape and polarity. Plays a role in cellular protein transport, including protein transport away from primary cilia. {ECO:0000250, ECO:0000269PubMed:23264467}.

Subcellular Localization

Cytoplasm, cytosol {ECO:0000250}. Cell projection, cilium {ECO:0000269PubMed:23264467}. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:23264467}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0003382	epithelial cell morphogenesis
GO:0006886	intracellular protein transport
GO:1901214	regulation of neuron death

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005813	centrosome
GO:0005814	centriole
GO:0005829	cytosol
GO:0005886	plasma membrane
GO:0072372	primary cilium

Protein Structure and Domains

PDB ID

MGI:1922945

InterPro

IPR019143 JNK/Rab-associated protein-1, N-terminal
IPR021563 Rab interacting lysosomal protein

PFAM

PF09744
PF11461

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q9JJC6

PhosphoSite

PhosphoSite-Q9JJC6

TrEMBL

UniProt Splice Variant

Entrez Gene

75695

UniGene

Mm.490836

RefSeq

NP_067405

MGI ID

MGI Symbol

Rilpl1

OMIM

CCDS

CCDS19678

HPRD

IMGT

EMBL

AB041584 BC051945 BC051946 BC058384

GenPept

AAH51945 AAH51946 AAH58384 BAA95067