Version 5.4
Mus musculus Protein: Astn1
Summary
InnateDB Protein IDBP-200751.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Astn1
Protein Name astrotactin 1
Synonyms Astn; GC14; mKIAA0289;
Species Mus musculus
Ensembl Protein ENSMUSP00000039711
InnateDB Gene IDBG-200749 (Astn1)
Protein Structure
UniProt Annotation
Function Neuronal adhesion molecule that is required for glial- guided migration of young postmitotic neuroblasts in cortical regions of developing brain, including cerebrum, hippocampus, cerebellum and olfactory bulb.
Subcellular Localization Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
Disease Associations
Tissue Specificity Expressed specifically in the brain. Expressed in the cerebellum, hippocampus, cerebrum and olfactory bulb.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 2 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 1 [view]
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005515 protein binding
Biological Process
GO:0001764 neuron migration
GO:0007158 neuron cell-cell adhesion
GO:0007626 locomotory behavior
GO:0016337 single organismal cell-cell adhesion
GO:0016477 cell migration
Cellular Component
GO:0005768 endosome
GO:0009897 external side of plasma membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1098567
InterPro IPR000742 Epidermal growth factor-like domain
IPR003961 Fibronectin, type III
IPR020864 Membrane attack complex component/perforin (MACPF) domain
PFAM PF00008
PF00041
PF01108
PF01823
PRINTS
PIRSF
SMART SM00181
SM00060
SM00457
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q61137
PhosphoSite PhosphoSite-Q61137
TrEMBL Q3UHD7
UniProt Splice Variant
Entrez Gene 11899
UniGene Mm.329586
RefSeq NP_031521
MGI ID
MGI Symbol Astn1
OMIM
CCDS CCDS56648
HPRD
IMGT
EMBL AB093222 AC091266 AC118728 AC119867 AC158910 AK147450 BC054545 BC094666 CH466520 U48797
GenPept AAC52516 AAH54545 AAH94666 BAC41406 BAE27920 EDL39354

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca