InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Gtf2h3

Summary

InnateDB Protein

IDBP-200828.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Gtf2h3

Protein Name

general transcription factor IIH, polypeptide 3

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000031333

InnateDB Gene

IDBG-200826 (Gtf2h3)

Protein Structure

UniProt Annotation

Function

Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. Anchors XPB (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 14 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	14 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004672	protein kinase activity
GO:0008094	DNA-dependent ATPase activity
GO:0008353	RNA polymerase II carboxy-terminal domain kinase activity
GO:0046872	metal ion binding
GO:0047485	protein N-terminus binding

Biological Process

GO:0006200	ATP catabolic process
GO:0006289	nucleotide-excision repair
GO:0006355	regulation of transcription, DNA-templated
GO:0006366	transcription from RNA polymerase II promoter
GO:0006468	protein phosphorylation