Version 5.4
Mus musculus Protein: Irf2bp2
Summary
InnateDB Protein IDBP-200866.7
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Irf2bp2
Protein Name interferon regulatory factor 2 binding protein 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000062753
InnateDB Gene IDBG-200864 (Irf2bp2)
Protein Structure
UniProt Annotation
Function Acts as a transcriptional corepressor in a IRF2- dependent manner, this repression is not mediated by histone deacetylase activities. Represses the NFAT1-dependent transactivation of NFAT-responsive promoters. Acts as a coactivator of VEGFA expression in cardiac and skeletal muscle (By similarity). {ECO:0000250}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 10 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 10 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0046872 metal ion binding
Biological Process
GO:0006351 transcription, DNA-templated
GO:0006355 regulation of transcription, DNA-templated
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:2443921
InterPro IPR022750 Interferon regulatory factor 2-binding protein 1 & 2, zinc finger
PFAM PF11261
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt E9Q1P8
PhosphoSite PhosphoSite-NP_001158070
TrEMBL
UniProt Splice Variant
Entrez Gene 270110
UniGene Mm.414045
RefSeq NP_001158070
MGI ID
MGI Symbol Irf2bp2
OMIM
CCDS CCDS52711
HPRD
IMGT
EMBL AC118255 AK087491
GenPept BAC39896

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca