Version 5.4
Homo sapiens Protein: SENP8
Summary
InnateDB Protein IDBP-20090.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol SENP8
Protein Name SUMO/sentrin specific peptidase family member 8
Synonyms
Species Homo sapiens
Ensembl Protein ENSP00000340505
InnateDB Gene IDBG-20088 (SENP8)
Protein Structure
UniProt Annotation
Function Protease that catalyzes two essential functions in the NEDD8 pathway: processing of full-length NEDD8 to its mature form and deconjugation of NEDD8 from targeted proteins such as cullins or p53. {ECO:0000269PubMed:12730221, ECO:0000269PubMed:12759362, ECO:0000269PubMed:12759363, ECO:0000269PubMed:15242646, ECO:0000269PubMed:15775960}.
Subcellular Localization
Disease Associations
Tissue Specificity Broadly expressed, with highest levels in kidney and pancreas. {ECO:0000269PubMed:12730221}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 25 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated
Total 25 [view]
Protein-Protein 25 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 1 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0008234 cysteine-type peptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
Protein Structure and Domains
PDB ID
InterPro IPR003653 Peptidase C48, SUMO/Sentrin/Ubl1
PFAM PF02902
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q96LD8
PhosphoSite PhosphoSite-Q96LD8
TrEMBL H3BTK5
UniProt Splice Variant
Entrez Gene 123228
UniGene Hs.513002
RefSeq NP_660205
HUGO HGNC:22992
OMIM 608659
CCDS CCDS10240
HPRD 09784
IMGT
EMBL AC020779 AF308450 AY008293 BC031411
GenPept AAG21828 AAH31411 AAL06294

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca