Version 5.4
Mus musculus Protein: Spcs2
Summary
InnateDB Protein IDBP-200909.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Spcs2
Protein Name signal peptidase complex subunit 2 homolog (S. cerevisiae)
Synonyms 5730406I15Rik; AA408713; mKIAA0102;
Species Mus musculus
Ensembl Protein ENSMUSP00000041152
InnateDB Gene IDBG-200907 (Spcs2)
Protein Structure
UniProt Annotation
Function Component of the microsomal signal peptidase complex which removes signal peptides from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. {ECO:0000250}.
Subcellular Localization Microsome membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 16 interaction(s) predicted by orthology.
Predicted by orthology
Total 16 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0008233 peptidase activity
Biological Process
GO:0006465 signal peptide processing
GO:0006508 proteolysis
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005787 signal peptidase complex
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1913874
InterPro IPR009582 Signal peptidase complex subunit 2
PFAM PF06703
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9CYN2
PhosphoSite PhosphoSite-Q9CYN2
TrEMBL
UniProt Splice Variant
Entrez Gene 66624
UniGene Mm.474212
RefSeq NP_079944
MGI ID
MGI Symbol Spcs2
OMIM
CCDS CCDS40033
HPRD
IMGT
EMBL AK014310 AK017504 AK077510 AK134578 AK168173 BC010547 BC050150
GenPept AAH10547 AAH50150 BAB29262 BAB30777 BAC36836 BAE22190 BAE40134

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca