InnateDB Protein
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IDBP-200915.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Timm22
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Protein Name
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translocase of inner mitochondrial membrane 22 homolog (yeast)
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Synonyms
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Tim22;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000021203
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InnateDB Gene
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IDBG-200913 (Timm22)
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Protein Structure
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Function |
Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity). {ECO:0000250}.
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Subcellular Localization |
Mitochondrion inner membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
1
[view]
|
Protein-Protein |
1
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
|
|
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1929742
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InterPro |
IPR003397
Mitochondrial inner membrane translocase subunit Tim17/Tim22/Tim23/peroxisomal protein PMP24
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PFAM |
PF02466
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q9CQ85
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
56322
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UniGene |
Mm.18803
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RefSeq |
NP_062792
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MGI ID |
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MGI Symbol |
Timm22
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OMIM |
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CCDS |
CCDS25065
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HPRD |
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IMGT |
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EMBL |
AF223950
AK012130
AK017389
AL663050
BC022610
BC055279
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GenPept |
AAF28359
AAH22610
AAH55279
BAB28051
BAB30726
CAI25857
CAI25858
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