InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Rnf169

Summary

InnateDB Protein

IDBP-200958.7

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Rnf169

Protein Name

ring finger protein 169

Synonyms

2900057K09Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000079631

InnateDB Gene

IDBG-200956 (Rnf169)

Protein Structure

UniProt Annotation

Function

Probable E3 ubiquitin-protein ligase that acts as a negative regulator of double-strand breaks (DSBs) repair following DNA damage. Recruited to DSB repair sites by recognizing and binding ubiquitin catalyzed by RNF168 and competes with TP53BP1 and BRCA1 for association with RNF168-modified chromatin, thereby acting as a negative regulator of DSBs repair. E3 ubiquitin- protein ligase activity is not required for regulation of DSBs repair (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus, nucleoplasm {ECO:0000250}. Note=Localizes to sites of double-strand breaks (DSBs) following DNA damage. Recruited to DSBs via recognition of RNF168-dependent ubiquitin products (By similarity). {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 3 interaction(s) predicted by orthology.

Predicted by orthology
Total	3 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016874	ligase activity
GO:0031491	nucleosome binding
GO:0070530	K63-linked polyubiquitin binding

Biological Process

GO:0006974	cellular response to DNA damage stimulus
GO:0016567	protein ubiquitination
GO:2000780	negative regulation of double-strand break repair

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005886	plasma membrane
GO:0035861	site of double-strand break
GO:0043231	intracellular membrane-bounded organelle