InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: POLB

Summary

InnateDB Protein

IDBP-20096.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

POLB

Protein Name

polymerase (DNA directed), beta

Synonyms

Species

Homo sapiens

Ensembl Protein

ENSP00000265421

InnateDB Gene

IDBG-20094 (POLB)

Protein Structure

UniProt Annotation

Function

Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. {ECO:0000269PubMed:11805079, ECO:0000269PubMed:21362556, ECO:0000269PubMed:9207062, ECO:0000269PubMed:9572863}.

Subcellular Localization

Nucleus. Cytoplasm. Note=Cytoplasmic in normal conditions. Translocates to the nucleus following DNA damage.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 24 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Experimentally validated
Total	24 [view]
Protein-Protein	22 [view]
Protein-DNA	2 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003677	DNA binding
GO:0003684	damaged DNA binding
GO:0003887	DNA-directed DNA polymerase activity
GO:0005515	protein binding
GO:0008017	microtubule binding
GO:0016779	nucleotidyltransferase activity
GO:0016829	lyase activity
GO:0019899	enzyme binding
GO:0034061	DNA polymerase activity
GO:0046872	metal ion binding

Biological Process

GO:0006261	DNA-dependent DNA replication
GO:0006281	DNA repair
GO:0006284	base-excision repair
GO:0006287	base-excision repair, gap-filling
GO:0006290	pyrimidine dimer repair
GO:0006974	cellular response to DNA damage stimulus
GO:0008630	intrinsic apoptotic signaling pathway in response to DNA damage
GO:0045471	response to ethanol
GO:0051402	neuron apoptotic process
GO:0071897	DNA biosynthetic process

Cellular Component

GO:0005634	nucleus
GO:0005654	nucleoplasm
GO:0005737	cytoplasm
GO:0005874	microtubule
GO:0005876	spindle microtubule

Protein Structure and Domains

PDB ID

InterPro

IPR002008 DNA polymerase family X, beta-like
IPR002054 DNA-directed DNA polymerase X
IPR003583 Helix-hairpin-helix DNA-binding motif, class 1
IPR010996 DNA polymerase beta-like, N-terminal domain
IPR018944 DNA polymerase lambda, fingers domain
IPR022312 DNA polymerase family X

PFAM

PF10391

PRINTS

PR00870
PR00869

PIRSF

SMART

SM00483
SM00278

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt