InnateDB Protein
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IDBP-200996.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Atp6v0a2
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Protein Name
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ATPase, H+ transporting, lysosomal V0 subunit A2
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Synonyms
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8430408C20Rik; AI385560; ATP6a2; Atp6n1d; Atp6n2; AW489264; C76904; ISF; J6B7; SHIF; Stv1; Tj6; TJ6M; TJ6s; V-ATPase 116 kDa; V-ATPase a2;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000039737
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InnateDB Gene
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IDBG-200994 (Atp6v0a2)
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Protein Structure
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Function |
Part of the proton channel of V-ATPases (By similarity). Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. {ECO:0000250, ECO:0000269PubMed:16415858}.
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Subcellular Localization |
Cell membrane {ECO:0000269PubMed:16415858}; Multi-pass membrane protein {ECO:0000269PubMed:16415858}. Endosome membrane {ECO:0000269PubMed:16415858}. Note=In kidney proximal tubules, detected in subapical early endosomes.
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Disease Associations |
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Tissue Specificity |
Relatively high expression in kidney and liver. Lower levels in the spleen, testis, and skeletal muscle. Also expressed in the thymus. {ECO:0000269PubMed:11375395}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 2 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated |
Total |
2
[view]
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Protein-Protein |
2
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
8 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005515
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protein binding
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GO:0015078
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hydrogen ion transmembrane transporter activity
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Biological Process |
GO:0015991
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ATP hydrolysis coupled proton transport
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Cellular Component |
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PDB ID |
MGI:104855
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InterPro |
IPR002490
V-type ATPase, V0 complex, 116kDa subunit family
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PFAM |
PF01496
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
P15920
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PhosphoSite |
PhosphoSite-P15920
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
21871
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UniGene |
Mm.1158
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RefSeq |
NP_035726
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MGI ID |
2LX4
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MGI Symbol |
Atp6v0a2
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OMIM |
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CCDS |
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HPRD |
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IMGT |
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EMBL |
AB022323
AF218252
AF388674
AK032909
AK155055
BC108991
BC108992
BC112905
M31226
X55184
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GenPept |
AAA39336
AAF59921
AAI08992
AAI08993
AAI12906
AAL57303
BAA93007
BAC28081
BAE33017
CAA38968
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