InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Pgm2l1

Summary

InnateDB Protein

IDBP-201093.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Pgm2l1

Protein Name

phosphoglucomutase 2-like 1

Synonyms

4931406N15Rik; AI553438; BM32A;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000081998

InnateDB Gene

IDBG-201091 (Pgm2l1)

Protein Structure

UniProt Annotation

Function

Glucose 1,6-bisphosphate synthase using 1,3- bisphosphoglycerate as a phosphate donor and a series of 1- phosphate sugars as acceptors, including glucose 1-phosphate, mannose 1-phosphate, ribose 1-phosphate and deoxyribose 1- phosphate. 5 or 6-phosphosugars are bad substrates, with the exception of glucose 6-phosphate. Also synthesizes ribose 1,5- bisphosphate. Has only low phosphopentomutase and phosphoglucomutase activities (By similarity). {ECO:0000250}.

Subcellular Localization

Disease Associations

Tissue Specificity

Expressed at highest levels in the brain and testis, at intermediate levels in thymus, spleen, lung and skeletal muscle, and at lowest levels in kidney, liver and heart. {ECO:0000269PubMed:17804405}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	0
Protein-DNA	1 [view]
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0016868	intramolecular transferase activity, phosphotransferases
GO:0047933	glucose-1,6-bisphosphate synthase activity

Biological Process

GO:0005975	carbohydrate metabolic process
GO:0006006	glucose metabolic process
GO:0016310	phosphorylation

Cellular Component

GO:0005829

cytosol

Protein Structure and Domains

PDB ID

MGI:1918224

InterPro

IPR005843 Alpha-D-phosphohexomutase, C-terminal
IPR005844 Alpha-D-phosphohexomutase, alpha/beta/alpha domain I
IPR005845 Alpha-D-phosphohexomutase, alpha/beta/alpha domain II
IPR005846 Alpha-D-phosphohexomutase, alpha/beta/alpha domain III
IPR016055 Alpha-D-phosphohexomutase, alpha/beta/alpha I/II/III

PFAM

PF00408
PF02878
PF02879
PF02880

PRINTS

PIRSF

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8CAA7

PhosphoSite