Version 5.4
Mus musculus Protein: Gosr1
Summary
InnateDB Protein IDBP-201127.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Gosr1
Protein Name golgi SNAP receptor complex member 1
Synonyms AI414660; AI426320; BB145494; GOS-28; GOSRI; GS28;
Species Mus musculus
Ensembl Protein ENSMUSP00000010536
InnateDB Gene IDBG-201125 (Gosr1)
Protein Structure
UniProt Annotation
Function Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide- sensitive factor) attachment protein receptor. May play a protective role against hydrogen peroxide induced cytotoxicity under glutathione depleted conditions in neuronal cells by regulating the intracellular ROS levels via inhibition of p38 MAPK (MAPK11, MAPK12, MAPK13 and MAPK14). Participates in docking and fusion stage of ER to cis-Golgi transport. Plays an important physiological role in VLDL-transport vesicle-Golgi fusion and thus in VLDL delivery to the hepatic cis-Golgi (By similarity). {ECO:0000250}.
Subcellular Localization Golgi apparatus membrane {ECO:0000269PubMed:15250942}; Single-pass type IV membrane protein {ECO:0000269PubMed:15250942}. Note=Localizes throughout the Golgi apparatus, with lowest levels in the trans-Golgi network. Enriched on vesicular components at the terminal rims of the Golgi. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 15 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 4 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 15 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0005484 SNAP receptor activity
Biological Process
GO:0006888 ER to Golgi vesicle-mediated transport
GO:0015031 protein transport
GO:0042147 retrograde transport, endosome to Golgi
Cellular Component
GO:0000139 Golgi membrane
GO:0005794 Golgi apparatus
GO:0005801 cis-Golgi network
GO:0016020 membrane
GO:0016021 integral component of membrane
Protein Structure and Domains
PDB ID MGI:1858260
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt O88630
PhosphoSite PhosphoSite-O88630
TrEMBL
UniProt Splice Variant
Entrez Gene 53334
UniGene Mm.414194
RefSeq NP_058090
MGI ID
MGI Symbol Gosr1
OMIM
CCDS CCDS25070
HPRD
IMGT
EMBL AF079901 AK133836 AK134515 AK147799 AK154972 AK161386 BC008542 BX000359 CH466596
GenPept AAC32189 AAH08542 BAE21873 BAE22167 BAE28147 BAE32964 BAE36365 CAI25288 EDL12868

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca