InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Padi6

Summary

InnateDB Protein

IDBP-201270.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Padi6

Protein Name

peptidyl arginine deiminase, type VI

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044044

InnateDB Gene

IDBG-201268 (Padi6)

Protein Structure

UniProt Annotation

Function

Catalyzes the deimination of arginine residues of proteins (By similarity). May be involved in cytoskeletal reorganization in the egg and early embryo. {ECO:0000250}.

Subcellular Localization

Cytoplasm {ECO:0000269PubMed:12654293}. Nucleus {ECO:0000269PubMed:12654293}. Note=Predominantly cytoplasmic (oocyte cytoplasmic sheets), also nuclear.

Disease Associations

Tissue Specificity

Expressed at very high levels in oocytes. Weakly expressed in testis. Expressed in primordial, primary, secondary and Graafian follicles, and in immature oocytes, mature eggs and blastocyst (at protein level). {ECO:0000269PubMed:12654293}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004668	protein-arginine deiminase activity
GO:0005509	calcium ion binding
GO:0005515	protein binding

Biological Process

GO:0007010	cytoskeleton organization
GO:0007028	cytoplasm organization
GO:0018101	protein citrullination
GO:0034613	cellular protein localization
GO:0043143	regulation of translation by machinery localization

Cellular Component

GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0045111	intermediate filament cytoskeleton

Protein Structure and Domains

PDB ID

MGI:2655198

InterPro

IPR008972 Cupredoxin
IPR013530 Protein-arginine deiminase, C-terminal
IPR013732 Protein-arginine deiminase (PAD) N-terminal
IPR013733 Protein-arginine deiminase (PAD), central domain
IPR016296 Protein-arginine deiminase, subgroup

PFAM

PF03068
PF08526
PF08527

PRINTS

PIRSF

PIRSF001247

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q8K3V4