InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Serpinc1

Summary

InnateDB Protein

IDBP-201303.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Serpinc1

Protein Name

serine (or cysteine) peptidase inhibitor, clade C (antithrombin), member 1

Synonyms

AI114908; At-3; At3; ATIII;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000068971

InnateDB Gene

IDBG-201299 (Serpinc1)

Protein Structure

UniProt Annotation

Function

Most important serine protease inhibitor in plasma that regulates the blood coagulation cascade. AT-III inhibits thrombin, matriptase-3/TMPRSS7, as well as factors IXa, Xa and XIa. Its inhibitory activity is greatly enhanced in the presence of heparin (By similarity). {ECO:0000250}.

Subcellular Localization

Secreted, extracellular space {ECO:0000250}.

Disease Associations

Tissue Specificity

Plasma.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 5 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.

Experimentally validated
Total	5 [view]
Protein-Protein	5 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	5 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0002020	protease binding
GO:0004867	serine-type endopeptidase inhibitor activity
GO:0005515	protein binding
GO:0008201	heparin binding

Biological Process

GO:0007584	response to nutrient
GO:0007596	blood coagulation
GO:0010951	negative regulation of endopeptidase activity
GO:0030162	regulation of proteolysis
GO:0050728	negative regulation of inflammatory response
GO:2000266	regulation of blood coagulation, intrinsic pathway