Version 5.4
Mus musculus Protein: Mcfd2
Summary
InnateDB Protein IDBP-201360.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Mcfd2
Protein Name multiple coagulation factor deficiency 2
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000024963
InnateDB Gene IDBG-201358 (Mcfd2)
Protein Structure
UniProt Annotation
Function The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins. {ECO:0000250}.
Subcellular Localization Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Endoplasmic reticulum {ECO:0000250}. Golgi apparatus {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 9 experimentally validated interaction(s) in this database.
They are also associated with 8 interaction(s) predicted by orthology.
Experimentally validated
Total 9 [view]
Protein-Protein 9 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 8 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005509 calcium ion binding
Biological Process
GO:0015031 protein transport
GO:0016192 vesicle-mediated transport
GO:0019752 carboxylic acid metabolic process
Cellular Component
GO:0005576 extracellular region
GO:0005783 endoplasmic reticulum
GO:0005793 endoplasmic reticulum-Golgi intermediate compartment
GO:0005794 Golgi apparatus
Protein Structure and Domains
PDB ID MGI:2183439
InterPro IPR002048 EF-hand domain
PFAM PF00036
PF13202
PF13405
PRINTS
PIRSF
SMART SM00054
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8K5B2
PhosphoSite PhosphoSite-Q8K5B2
TrEMBL Q99KV4
UniProt Splice Variant
Entrez Gene 193813
UniGene Mm.473270
RefSeq NP_647456
MGI ID
MGI Symbol Mcfd2
OMIM
CCDS CCDS29015
HPRD
IMGT
EMBL AC084383 AF475283 AK033139 AK075781 AK077139 AK077631 AK141599 AK151803 BC003996 CH466537 GQ896355 GQ896356
GenPept AAH03996 AAM28464 ACX48448 ACX48449 BAC28169 BAC35955 BAC36638 BAC36914 BAE24757 BAE30702 EDL38625 EDL38627

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca