Version 5.4
Mus musculus Protein: Dars2
Summary
InnateDB Protein IDBP-201380.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Dars2
Protein Name aspartyl-tRNA synthetase 2 (mitochondrial)
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000041851
InnateDB Gene IDBG-201378 (Dars2)
Protein Structure
UniProt Annotation
Function
Subcellular Localization Mitochondrion matrix {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.
Predicted by orthology
Total 7 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0000166 nucleotide binding
GO:0003676 nucleic acid binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004815 aspartate-tRNA ligase activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016874 ligase activity
GO:0042803 protein homodimerization activity
GO:0050560 aspartate-tRNA(Asn) ligase activity
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0043039 tRNA aminoacylation
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005759 mitochondrial matrix
Protein Structure and Domains
PDB ID MGI:2442510
InterPro IPR002312 Aspartyl/Asparaginyl-tRNA synthetase, class IIb
IPR004115 GAD-like domain
IPR004364 Aminoacyl-tRNA synthetase, class II (D/K/N)
IPR004365 OB-fold nucleic acid binding domain, AA-tRNA synthetase-type
IPR004524 Aspartate-tRNA ligase, class IIb, bacterial/mitochondrial-type
IPR006195 Aminoacyl-tRNA synthetase, class II
IPR012340 Nucleic acid-binding, OB-fold
IPR018149 Lysyl-tRNA synthetase, class II, C-terminal
IPR029351 GAD domain
PFAM PF00152
PF01336
PF02938
PRINTS PR01042
PR00982
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q8BIP0
PhosphoSite PhosphoSite-Q8BIP0
TrEMBL Q8BIE1
UniProt Splice Variant
Entrez Gene 226539
UniGene Mm.28125
RefSeq NP_766232
MGI ID
MGI Symbol Dars2
OMIM
CCDS CCDS15413
HPRD
IMGT
EMBL AK037337 AK083300 AK138809 BC076606 BC089191
GenPept AAH76606 AAH89191 BAC29789 BAC38851 BAE23785

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca