InnateDB Protein
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IDBP-201389.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Depdc1a
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Protein Name
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DEP domain containing 1a
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Synonyms
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5830484J08Rik; Depdc1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000029825
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InnateDB Gene
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IDBG-201387 (Depdc1a)
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Protein Structure
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Function |
May be involved in transcriptional regulation as a transcriptional corepressor. The DEPDC1A-ZNF224 complex may play a critical role in bladder carcinogenesis by repressing the transcription of the A20 gene, leading to transport of NF-KB protein into the nucleus, resulting in suppression of apoptosis of bladder cancer cells (By similarity). {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000250}. Note=Colocalizes with ZNF224 at the nucleus. {ECO:0000250}.
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Disease Associations |
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Tissue Specificity |
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 5 interaction(s) predicted by orthology.
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Predicted by orthology |
Total |
5 [view]
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Molecular Function |
Accession |
GO Term |
GO:0005096
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GTPase activator activity
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1923381
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InterPro |
IPR000591
DEP domain
IPR008936
Rho GTPase activation protein
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PFAM |
PF00610
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PRINTS |
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PIRSF |
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SMART |
SM00049
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CIG0
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PhosphoSite |
PhosphoSite-Q8CIG0
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
76131
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UniGene |
Mm.473495
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RefSeq |
NP_083799
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MGI ID |
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MGI Symbol |
Depdc1a
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OMIM |
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CCDS |
CCDS17936
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HPRD |
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IMGT |
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EMBL |
AK050456
AK088719
BC005799
BC023934
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GenPept |
AAH05799
AAH23934
BAC34267
BAC40526
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