InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Padi2

Summary

InnateDB Protein

IDBP-201407.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Padi2

Protein Name

peptidyl arginine deiminase, type II

Synonyms

mKIAA0994; Pdi; Pdi2;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000030765

InnateDB Gene

IDBG-201405 (Padi2)

Protein Structure

UniProt Annotation

Function

Catalyzes the deimination of arginine residues of proteins.

Subcellular Localization

Cytoplasm {ECO:0000250}.

Disease Associations

Tissue Specificity

Expressed in various tissues including muscle, uterus, spinal cord, salivary gland and pancreas. {ECO:0000269PubMed:1778991}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004668	protein-arginine deiminase activity
GO:0005509	calcium ion binding
GO:0030331	estrogen receptor binding

Biological Process

GO:0010848	regulation of chromatin disassembly
GO:0018101	protein citrullination
GO:0021762	substantia nigra development
GO:0030520	intracellular estrogen receptor signaling pathway
GO:0036413	histone H3-R26 citrullination
GO:0048096	chromatin-mediated maintenance of transcription
GO:0070100	negative regulation of chemokine-mediated signaling pathway
GO:1901624	negative regulation of lymphocyte chemotaxis

Cellular Component

GO:0005737	cytoplasm
GO:0035327	transcriptionally active chromatin
GO:0070062	extracellular vesicular exosome

Protein Structure and Domains

PDB ID

MGI:1338892

InterPro

IPR008972 Cupredoxin
IPR013530 Protein-arginine deiminase, C-terminal
IPR013732 Protein-arginine deiminase (PAD) N-terminal
IPR013733 Protein-arginine deiminase (PAD), central domain
IPR016296 Protein-arginine deiminase, subgroup

PFAM

PF03068
PF08526
PF08527

PRINTS

PIRSF

PIRSF001247

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt

Q08642