Version 5.4
Mus musculus Protein: Ankrd13b
Summary
InnateDB Protein IDBP-201514.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ankrd13b
Protein Name ankyrin repeat domain 13b
Synonyms
Species Mus musculus
Ensembl Protein ENSMUSP00000090568
InnateDB Gene IDBG-201512 (Ankrd13b)
Protein Structure
UniProt Annotation
Function Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity). {ECO:0000250}.
Subcellular Localization Cell membrane. Late endosome. Early endosome. Note=Interaction with EGFR may enhance association with the cell membrane. {ECO:0000250}.
Disease Associations
Tissue Specificity
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 2 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
GO:0005515 protein binding
Biological Process
GO:0008150 biological_process
Cellular Component
GO:0005575 cellular_component
GO:0005769 early endosome
GO:0005770 late endosome
GO:0005886 plasma membrane
Protein Structure and Domains
PDB ID MGI:2144501
InterPro IPR002110 Ankyrin repeat
IPR020683 Ankyrin repeat-containing domain
IPR021832 Ankyrin repeat domain-containing protein 13
PFAM PF00023
PF13606
PF11929
PF12796
PF11904
PRINTS PR01415
PIRSF
SMART SM00248
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q5F259
PhosphoSite PhosphoSite-Q5F259
TrEMBL
UniProt Splice Variant
Entrez Gene 268445
UniGene Mm.39296
RefSeq NP_766533
MGI ID
MGI Symbol Ankrd13b
OMIM
CCDS CCDS36233
HPRD
IMGT
EMBL AL607072 BC071189 BC151158
GenPept AAH71189 AAI51159 CAI52037

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca