InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Ankrd13b

Summary

InnateDB Protein

IDBP-201516.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Ankrd13b

Protein Name

ankyrin repeat domain 13b

Synonyms

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073584

InnateDB Gene

IDBG-201512 (Ankrd13b)

Protein Structure

UniProt Annotation

Function

Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand- activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane (By similarity). {ECO:0000250}.

Subcellular Localization

Cell membrane. Late endosome. Early endosome. Note=Interaction with EGFR may enhance association with the cell membrane. {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.

Experimentally validated
Total	1 [view]
Protein-Protein	1 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	2 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function
GO:0005515	protein binding

Biological Process

GO:0008150

biological_process

Cellular Component

GO:0005575	cellular_component
GO:0005769	early endosome
GO:0005770	late endosome
GO:0005886	plasma membrane

Protein Structure and Domains

PDB ID

MGI:2144501

InterPro

IPR002110 Ankyrin repeat
IPR003903 Ubiquitin interacting motif
IPR020683 Ankyrin repeat-containing domain
IPR021832 Ankyrin repeat domain-containing protein 13

PFAM

PF00023
PF13606
PF02809
PF11929
PF12796
PF11904

PRINTS

PR01415

PIRSF

SMART

SM00248
SM00726

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt