InnateDB Protein
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IDBP-201610.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Plekhb1
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Protein Name
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pleckstrin homology domain containing, family B (evectins) member 1
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Synonyms
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AI315628; evt-1; PHR1; Phret1;
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000078175
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InnateDB Gene
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IDBG-201608 (Plekhb1)
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Protein Structure
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Function |
Required for proper localization of retinogeniculate projections but not for eye-specific segregation. {ECO:0000269PubMed:19371781}.
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Subcellular Localization |
Membrane {ECO:0000269PubMed:20301200}. Cytoplasm {ECO:0000269PubMed:20301200}. Note=Membrane-associated. Highly expressed in the outer segments of photoreceptor cells, both in rods and cones. Localizes to the apical juxta-nuclear Golgi region of the cytoplasm.
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Disease Associations |
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Tissue Specificity |
Highly expressed in retina and brain. In retina, abundantly expressed in photoreceptors. Isoform 4 is the predominant isoform expressed in mature olfactory receptor neurons and vestibular and cochlear hair cells. Also expressed in cells with possible sensory function, including peripheral retinal ganglion cells, cochlear interdental cells, and neurons of the circumventricular organ (at protein level). {ECO:0000269PubMed:10585447, ECO:0000269PubMed:15456885, ECO:0000269PubMed:20301200}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:1351469
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InterPro |
IPR001849
Pleckstrin homology domain
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PFAM |
PF00169
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PRINTS |
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PIRSF |
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SMART |
SM00233
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TIGRFAMs |
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Modification |
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SwissProt |
Q9QYE9
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PhosphoSite |
PhosphoSite-Q9QYE9
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TrEMBL |
D3YZT7
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UniProt Splice Variant |
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Entrez Gene |
27276
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UniGene |
Mm.490749
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RefSeq |
NP_038774
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MGI ID |
2D9V
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MGI Symbol |
Plekhb1
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OMIM |
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CCDS |
CCDS21504
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HPRD |
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IMGT |
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EMBL |
AC124531
AF000272
AF071000
AF071001
AF100613
AF101053
AK005102
BC024756
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GenPept |
AAD32952
AAF16676
AAF16683
AAF18571
AAF18933
AAH24756
BAB23819
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