InnateDB Protein
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IDBP-201635.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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Crocc
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Protein Name
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ciliary rootlet coiled-coil, rootletin
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Synonyms
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Species
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Mus musculus
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Ensembl Protein
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ENSMUSP00000095425
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InnateDB Gene
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IDBG-201629 (Crocc)
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Protein Structure
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Function |
Major structural component of the ciliary rootlet, a cytoskeletal-like structure in ciliated cells which originates from the basal body at the proximal end of a cilium and extends proximally toward the cell nucleus. Contributes to centrosome cohesion before mitosis. {ECO:0000250UniProtKB:Q5TZA2, ECO:0000269PubMed:12427867}.
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Subcellular Localization |
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole {ECO:0000269PubMed:12427867, ECO:0000269PubMed:16339073}. Note=In ciliated cells, associated with ciliary rootlets. In non- ciliated cells, localized between, around and at the proximal ends of the centrioles. Dissociates from the centrioles at the onset of mitosis and reassociates with them at anaphase.
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Disease Associations |
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Tissue Specificity |
Highest expression detected in photoreceptor cells of retina. Expressed at lower levels in brain, trachea and kidney. Detected in all major ciliated epithelia. During embryonic development, enriched along the apical domains of neuroepithelium in brain ventricular zone, in primordia of retinal pigment epithelia and in neural retina. {ECO:0000269PubMed:12427867}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 7 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.
Experimentally validated |
Total |
7
[view]
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Protein-Protein |
7
[view]
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Protein-DNA |
0
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
1 [view]
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Molecular Function |
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Biological Process |
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Cellular Component |
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PDB ID |
MGI:3529431
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InterPro |
IPR009053
Prefoldin
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PFAM |
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PRINTS |
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PIRSF |
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SMART |
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TIGRFAMs |
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Modification |
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SwissProt |
Q8CJ40
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PhosphoSite |
PhosphoSite-Q8CJ40
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
230872
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UniGene |
Mm.80685
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RefSeq |
NP_001139430
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MGI ID |
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MGI Symbol |
Crocc
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OMIM |
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CCDS |
CCDS51346
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HPRD |
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IMGT |
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EMBL |
AF527975
AK122285
AL645625
BC027090
BC054054
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GenPept |
AAH27090
AAH54054
AAN73044
BAC65567
CAM16757
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