Version 5.4
Mus musculus Protein: Ccndbp1
Summary
InnateDB Protein IDBP-201647.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Ccndbp1
Protein Name cyclin D-type binding-protein 1
Synonyms AU022347; DIP1; GCIP; Maid; SECC-8; SSEC-8;
Species Mus musculus
Ensembl Protein ENSMUSP00000097087
InnateDB Gene IDBG-201641 (Ccndbp1)
Protein Structure
UniProt Annotation
Function May negatively regulate cell cycle progression. May act at least in part via inhibition of the cyclin-D1/CDK4 complex, thereby preventing phosphorylation of RB1 and blocking E2F- dependent transcription (By similarity). May be required for hepatocyte proliferation. {ECO:0000250, ECO:0000269PubMed:17256742}.
Subcellular Localization Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}.
Disease Associations
Tissue Specificity Expressed at high levels in brain, intestine, muscle and ovary and at lower levels in heart, kidney, liver, lung, spleen and testis. {ECO:0000269PubMed:9186056}.
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 1 experimentally validated interaction(s) in this database.
They are also associated with 12 interaction(s) predicted by orthology.
Experimentally validated
Total 1 [view]
Protein-Protein 1 [view]
Protein-DNA 0
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 12 [view]
Gene Ontology

Molecular Function
Accession GO Term
Biological Process
GO:0007049 cell cycle
GO:0051726 regulation of cell cycle
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
Protein Structure and Domains
PDB ID MGI:109595
InterPro
PFAM
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q3TVC7
PhosphoSite PhosphoSite-
TrEMBL
UniProt Splice Variant
Entrez Gene 17151
UniGene Mm.7838
RefSeq XP_006498914
MGI ID
MGI Symbol Ccndbp1
OMIM
CCDS
HPRD
IMGT
EMBL AK144883 AK154285 AK160205 AK163150 AK167345 AL844548 BC001984 BC004673 BC005802 U50734
GenPept AAB58118 AAH01984 AAH04673 AAH05802 BAE26115 BAE32489 BAE35692 BAE37214 BAE39444 CAM19012 CAM19013 CAM19014

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca