InnateDB: Systems Biology of the Innate Immune Response

Homo sapiens Protein: ISL1

Summary

InnateDB Protein

IDBP-20179.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

ISL1

Protein Name

ISL LIM homeobox 1

Synonyms

Isl-1; ISLET1;

Species

Homo sapiens

Ensembl Protein

ENSP00000230658

InnateDB Gene

IDBG-20177 (ISL1)

Protein Structure

UniProt Annotation

Function

Binds and regulates the promoters of the insulin, glucagon and somatostatin genes. Involved in the specificarion of motor neurons in cooperation with LHX3 and LDB1 (By similarity). {ECO:0000250}.

Subcellular Localization

Nucleus.

Disease Associations

Tissue Specificity

Expressed in subsets of neurons of the adrenal medulla and dorsal root ganglion, inner nuclear and ganglion cell layers in the retina, the pineal and some regions of the brain.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 21 experimentally validated interaction(s) in this database.
They are also associated with 7 interaction(s) predicted by orthology.

Experimentally validated
Total	21 [view]
Protein-Protein	21 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Predicted by orthology
Total	7 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0001102	RNA polymerase II activating transcription factor binding
GO:0001105	RNA polymerase II transcription coactivator activity
GO:0001158	enhancer sequence-specific DNA binding
GO:0003677	DNA binding
GO:0003682	chromatin binding
GO:0003700	sequence-specific DNA binding transcription factor activity
GO:0005515	protein binding
GO:0008270	zinc ion binding
GO:0016922	ligand-dependent nuclear receptor binding
GO:0030331	estrogen receptor binding
GO:0043425	bHLH transcription factor binding
GO:0043565	sequence-specific DNA binding

Biological Process

GO:0000122	negative regulation of transcription from RNA polymerase II promoter
GO:0001755	neural crest cell migration
GO:0003007	heart morphogenesis
GO:0003139	secondary heart field specification
GO:0003148	outflow tract septum morphogenesis
GO:0003151	outflow tract morphogenesis
GO:0003203	endocardial cushion morphogenesis
GO:0003215	cardiac right ventricle morphogenesis
GO:0003266	regulation of secondary heart field cardioblast proliferation
GO:0006355	regulation of transcription, DNA-templated
GO:0007507	heart development
GO:0008284	positive regulation of cell proliferation
GO:0010468	regulation of gene expression
GO:0010575	positive regulation vascular endothelial growth factor production
GO:0021520	spinal cord motor neuron cell fate specification
GO:0021522	spinal cord motor neuron differentiation
GO:0021524	visceral motor neuron differentiation
GO:0021559	trigeminal nerve development
GO:0021983	pituitary gland development
GO:0030182	neuron differentiation
GO:0031016	pancreas development
GO:0031103	axon regeneration
GO:0031290	retinal ganglion cell axon guidance
GO:0032024	positive regulation of insulin secretion
GO:0032725	positive regulation of granulocyte macrophage colony-stimulating factor production
GO:0032729	positive regulation of interferon-gamma production
GO:0032730	positive regulation of interleukin-1 alpha production
GO:0032731	positive regulation of interleukin-1 beta production
GO:0032735	positive regulation of interleukin-12 production
GO:0032755	positive regulation of interleukin-6 production
GO:0032760	positive regulation of tumor necrosis factor production
GO:0033147	negative regulation of intracellular estrogen receptor signaling pathway
GO:0042517	positive regulation of tyrosine phosphorylation of Stat3 protein
GO:0043388	positive regulation of DNA binding
GO:0043524	negative regulation of neuron apoptotic process
GO:0045665	negative regulation of neuron differentiation
GO:0045766	positive regulation of angiogenesis
GO:0045944	positive regulation of transcription from RNA polymerase II promoter
GO:0048663	neuron fate commitment
GO:0048665	neuron fate specification
GO:0048762	mesenchymal cell differentiation
GO:0048880	sensory system development
GO:0048935	peripheral nervous system neuron development
GO:0048936	peripheral nervous system neuron axonogenesis
GO:0050728	negative regulation of inflammatory response
GO:0055010	ventricular cardiac muscle tissue morphogenesis
GO:0060037	pharyngeal system development
GO:0060379	cardiac muscle cell myoblast differentiation
GO:0060384	innervation
GO:0060413	atrial septum morphogenesis
GO:0060913	cardiac cell fate determination
GO:0071385	cellular response to glucocorticoid stimulus
GO:0071657	positive regulation of granulocyte colony-stimulating factor production
GO:0090074	negative regulation of protein homodimerization activity
GO:0090090	negative regulation of canonical Wnt signaling pathway
GO:1901258	positive regulation of macrophage colony-stimulating factor production