Version 5.4
Mus musculus Protein: Necap2
Summary
InnateDB Protein IDBP-201834.6
Last Modified 2014-10-13 [Report errors or provide feedback]
Gene Symbol Necap2
Protein Name NECAP endocytosis associated 2
Synonyms 1110005F07Rik; AA409105; C78898;
Species Mus musculus
Ensembl Protein ENSMUSP00000030760
InnateDB Gene IDBG-201832 (Necap2)
Protein Structure
UniProt Annotation
Function Involved in endocytosis. {ECO:0000250}.
Subcellular Localization Cytoplasmic vesicle, clathrin-coated vesicle membrane {ECO:0000269PubMed:14555962}. Cell membrane {ECO:0000269PubMed:14555962}. Note=Colocalizes with AP-2 at the plasma membrane.
Disease Associations
Tissue Specificity Expressed in brain, heart, kidney, liver, lung, skeletal muscles and testis (at protein level).
Comments
Interactions
Number of Interactions This gene and/or its encoded proteins are associated with 4 experimentally validated interaction(s) in this database.
They are also associated with 13 interaction(s) predicted by orthology.
Experimentally validated
Total 4 [view]
Protein-Protein 3 [view]
Protein-DNA 1 [view]
Protein-RNA 0
DNA-DNA 0
RNA-RNA 0
DNA-RNA 0
Predicted by orthology
Total 13 [view]
Gene Ontology

Molecular Function
Accession GO Term
GO:0003674 molecular_function
Biological Process
GO:0006897 endocytosis
GO:0008150 biological_process
GO:0015031 protein transport
Cellular Component
GO:0005622 intracellular
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0030125 clathrin vesicle coat
Protein Structure and Domains
PDB ID MGI:1913397
InterPro IPR012466 Adaptin ear-binding coat-associated protein 1 NECAP-1
PFAM PF07933
PRINTS
PIRSF
SMART
TIGRFAMs
Post-translational Modifications
Modification
Cross-References
SwissProt Q9D1J1
PhosphoSite PhosphoSite-Q9D1J1
TrEMBL
UniProt Splice Variant
Entrez Gene 66147
UniGene Mm.399322
RefSeq NP_079659
MGI ID
MGI Symbol Necap2
OMIM
CCDS CCDS18862
HPRD
IMGT
EMBL AK003463 AK009714 AK155871 BC037069 BK000657
GenPept AAH37069 BAB22803 BAB26458 BAE33474 DAA01434

If you use InnateDB for your research, please cite the following publication:

Breuer et al., InnateDB: systems biology of innate immunity and beyond - recent updates and continuing curation. Nucl. Acids Res. (2013) 41 (D1) 

InnateDB is being developed jointly by the Brinkman Laboratory (Simon Fraser University, British Columbia, Canada), the Hancock Laboratory (University of British Columbia, Vancouver, British Columbia) and the Lynn EMBL Australia Group (South Australian Health & Medical Research Institute and Flinders University, Adelaide, Australia).

Funding is currently provided by Allergen and EMBL Australia. Previous funding has been provided by Genome Canada, the Foundation for the National Institutes of Health through the Grand Challenges in Global Health initiative and by Teagasc. InnateDB curated interactions are licensed under the Design Science License. All other data is licensed under the terms of the originating database. Contact: innatedb-mail@sfu.ca