Mus musculus Protein: Smarcc1 | |||||||||||||||||||||||
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Summary | |||||||||||||||||||||||
InnateDB Protein | IDBP-201864.6 | ||||||||||||||||||||||
Last Modified | 2014-10-13 [Report errors or provide feedback] | ||||||||||||||||||||||
Gene Symbol | Smarcc1 | ||||||||||||||||||||||
Protein Name | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily c, member 1 | ||||||||||||||||||||||
Synonyms | AI115498; BAF155; Rsc8; SRG3; | ||||||||||||||||||||||
Species | Mus musculus | ||||||||||||||||||||||
Ensembl Protein | ENSMUSP00000086094 | ||||||||||||||||||||||
InnateDB Gene | IDBG-201862 (Smarcc1) | ||||||||||||||||||||||
Protein Structure | |||||||||||||||||||||||
UniProt Annotation | |||||||||||||||||||||||
Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). May stimulate the ATPase activity of the catalytic subunit of the complex. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR- mediated transrepression of the CYP27B1 gene (By similarity). Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron- specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. {ECO:0000250, ECO:0000269PubMed:11604513, ECO:0000269PubMed:17640523}. | ||||||||||||||||||||||
Subcellular Localization | Nucleus. | ||||||||||||||||||||||
Disease Associations | |||||||||||||||||||||||
Tissue Specificity | Highly expressed in adult brain, testis and thymus. | ||||||||||||||||||||||
Comments | |||||||||||||||||||||||
Interactions | |||||||||||||||||||||||
Number of Interactions |
This gene and/or its encoded proteins are associated with 43 experimentally validated interaction(s) in this database.
They are also associated with 98 interaction(s) predicted by orthology.
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Gene Ontology | |||||||||||||||||||||||
Molecular Function |
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Biological Process |
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Cellular Component |
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Protein Structure and Domains | |||||||||||||||||||||||
PDB ID | MGI:1203524 | ||||||||||||||||||||||
InterPro |
IPR000953
Chromo domain/shadow IPR001005 SANT/Myb domain IPR001357 BRCT domain IPR007526 SWIRM domain IPR009057 Homeodomain-like IPR017877 Myb-like domain |
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PFAM |
PF00249
PF00533 PF12738 PF04433 |
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PRINTS | |||||||||||||||||||||||
PIRSF | |||||||||||||||||||||||
SMART |
SM00298
SM00717 SM00292 |
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TIGRFAMs | |||||||||||||||||||||||
Post-translational Modifications | |||||||||||||||||||||||
Modification | |||||||||||||||||||||||
Cross-References | |||||||||||||||||||||||
SwissProt | P97496 | ||||||||||||||||||||||
PhosphoSite | PhosphoSite-P97496 | ||||||||||||||||||||||
TrEMBL | |||||||||||||||||||||||
UniProt Splice Variant | |||||||||||||||||||||||
Entrez Gene | 20588 | ||||||||||||||||||||||
UniGene | Mm.85410 | ||||||||||||||||||||||
RefSeq | NP_033237 | ||||||||||||||||||||||
MGI ID | |||||||||||||||||||||||
MGI Symbol | Smarcc1 | ||||||||||||||||||||||
OMIM | |||||||||||||||||||||||
CCDS | CCDS23561 | ||||||||||||||||||||||
HPRD | |||||||||||||||||||||||
IMGT | |||||||||||||||||||||||
EMBL | BC052423 BC053064 U85614 | ||||||||||||||||||||||
GenPept | AAB42085 AAH52423 AAH53064 | ||||||||||||||||||||||