InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Sez6

Summary

InnateDB Protein

IDBP-201980.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Sez6

Protein Name

seizure related gene 6

Synonyms

BSRP-C; D11Bhm177e; sez-6;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000000646

InnateDB Gene

IDBG-201978 (Sez6)

Protein Structure

UniProt Annotation

Function

May play a role in cell-cell recognition and in neuronal membrane signaling. Seems to be important for the achievement of the necessary balance between dendrite elongation and branching during the elaboration of a complex dendritic arbor. Involved in the development of appropriate excitatory synaptic connectivity. {ECO:0000269PubMed:18031681}.

Subcellular Localization

Isoform 1: Cell membrane; Single-pass type I membrane protein. Cell projection, dendrite. Note=Localized on dendrites and in the postsynaptic fraction. Does not appear to be enriched at synapses, at least not in the presynaptic axon terminal.Isoform 2: Cell membrane; Single-pass type I membrane protein. Cell junction, synapse. Cell projection, dendrite. Note=Localized on dendrites and in the synaptic and postsynaptic fraction.Isoform 3: Secreted {ECO:0000305}. Cytoplasm.

Disease Associations

Tissue Specificity

Brain-specific. Expressed in extrasynaptic and synaptic subcellular fractions (at protein level). Expression correlates with the most active periods of cortical neurogenesis and neuronal maturation. Expression is restricted to the gray matter with higher levels in the forebrain including the olfactory bulb, anterior olfactory nuclei, olfactory tubercle, striatum, hippocampal CA1 pyramidal cell layer and cerebral cortex. Expression is up-regulated with the convulsant drug, pentylenetetrazole. {ECO:0000269PubMed:16814779, ECO:0000269PubMed:7488116, ECO:0000269PubMed:7723619}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.
They are also associated with 1 interaction(s) predicted by orthology.

Predicted by orthology
Total	1 [view]

Gene Ontology

Molecular Function

Accession	GO Term
GO:0003674	molecular_function

Biological Process

GO:0008344	adult locomotory behavior
GO:0021680	cerebellar Purkinje cell layer development
GO:0050773	regulation of dendrite development
GO:0060074	synapse maturation
GO:0060079	regulation of excitatory postsynaptic membrane potential
GO:0090036	regulation of protein kinase C signaling
GO:1900006	positive regulation of dendrite development
GO:2000171	negative regulation of dendrite development

Cellular Component

GO:0005615	extracellular space
GO:0005783	endoplasmic reticulum
GO:0005886	plasma membrane
GO:0016021	integral component of membrane
GO:0030054	cell junction
GO:0043025	neuronal cell body
GO:0043197	dendritic spine
GO:0043198	dendritic shaft
GO:0045202	synapse
GO:0048471	perinuclear region of cytoplasm
GO:0097440	apical dendrite