InnateDB Protein
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IDBP-20199.6
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Last Modified
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2014-10-13 [Report errors or provide feedback]
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Gene Symbol
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HOPX
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Protein Name
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HOP homeobox
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Synonyms
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Species
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Homo sapiens
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Ensembl Protein
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ENSP00000315198
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InnateDB Gene
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IDBG-20189 (HOPX)
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Protein Structure
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Function |
Atypical homeodomain protein which does not bind DNA and is required to modulate cardiac growth and development. Acts via its interaction with SRF, thereby modulating the expression of SRF-dependent cardiac-specific genes and cardiac development. Prevents SRF-dependent transcription either by inhibiting SRF binding to DNA or by recruiting histone deacetylase (HDAC) proteins that prevent transcription by SRF. Overexpression causes cardiac hypertrophy (By similarity). May act as a tumor suppressor. {ECO:0000250}.
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Subcellular Localization |
Nucleus {ECO:0000255PROSITE- ProRule:PRU00108}.
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Disease Associations |
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Tissue Specificity |
Widely expressed. Expressed in the heart, brain, placenta, lung, skeletal and smooth muscles, uterus, urinary bladder, kidney and spleen. Down-regulated in some types of cancer such as lung cancer, choriocarcinoma, head and neck squamous cell carcinoma and oral squamous cell carcinoma. {ECO:0000269PubMed:12573257, ECO:0000269PubMed:12759545}.
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Comments |
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Number of Interactions
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This gene and/or its encoded proteins are associated with 10 experimentally validated interaction(s) in this database.
They are also associated with 2 interaction(s) predicted by orthology.
Experimentally validated |
Total |
10
[view]
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Protein-Protein |
9
[view]
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Protein-DNA |
1
[view]
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Protein-RNA |
0
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DNA-DNA |
0
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RNA-RNA |
0
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DNA-RNA |
0
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Predicted by orthology |
Total |
2 [view]
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Molecular Function |
Accession |
GO Term |
GO:0003677
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DNA binding
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GO:0003700
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sequence-specific DNA binding transcription factor activity
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GO:0043565
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sequence-specific DNA binding
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Biological Process |
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Cellular Component |
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PDB ID |
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InterPro |
IPR001356
Homeobox domain
IPR009057
Homeodomain-like
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PFAM |
PF00046
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PRINTS |
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PIRSF |
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SMART |
SM00389
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TIGRFAMs |
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Modification |
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SwissProt |
Q9BPY8
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PhosphoSite |
PhosphoSite-
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TrEMBL |
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UniProt Splice Variant |
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Entrez Gene |
84525
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UniGene |
Hs.619396
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RefSeq |
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HUGO |
HGNC:24961
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OMIM |
607275
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CCDS |
CCDS3507
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HPRD |
06280
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IMGT |
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EMBL |
AB059408
AB059409
AB059410
AC108215
AF454763
AF492675
AF492676
AF492677
AF492678
AF492679
AF492680
AF492681
AK289707
BC014225
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GenPept |
AAH14225
AAL56613
AAM46827
AAM46828
AAM46829
AAM46830
AAM46831
AAM46832
AAM46833
BAB40926
BAB40927
BAB40928
BAF82396
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