InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Fmo2

Summary

InnateDB Protein

IDBP-202021.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Fmo2

Protein Name

flavin containing monooxygenase 2

Synonyms

2310008D08Rik; 2310042I22Rik; AW107733;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000044405

InnateDB Gene

IDBG-202019 (Fmo2)

Protein Structure

UniProt Annotation

Function

This protein is involved in the oxidative metabolism of a variety of xenobiotics such as drugs and pesticides. Shows catalytic activity towards methimazole, thiourea, trimethylamine, and the insecticide phorate.

Subcellular Localization

Microsome membrane {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000250}.

Disease Associations

Tissue Specificity

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 3 experimentally validated interaction(s) in this database.

Experimentally validated
Total	3 [view]
Protein-Protein	3 [view]
Protein-DNA	0
Protein-RNA	0
DNA-DNA	0
RNA-RNA	0
DNA-RNA	0

Gene Ontology

Molecular Function

Accession	GO Term
GO:0004497	monooxygenase activity
GO:0004499	N,N-dimethylaniline monooxygenase activity
GO:0016491	oxidoreductase activity
GO:0050660	flavin adenine dinucleotide binding
GO:0050661	NADP binding

Biological Process

GO:0006082	organic acid metabolic process
GO:0006739	NADP metabolic process
GO:0006805	xenobiotic metabolic process
GO:0009404	toxin metabolic process
GO:0017144	drug metabolic process
GO:0055114	oxidation-reduction process
GO:0070995	NADPH oxidation
GO:0072592	oxygen metabolic process

Cellular Component

GO:0005789	endoplasmic reticulum membrane
GO:0016020	membrane
GO:0016021	integral component of membrane

Protein Structure and Domains

PDB ID

MGI:1916776

InterPro

IPR000960 Flavin monooxygenase FMO
IPR002253 Flavin monooxygenase (FMO) 1
IPR002254 Flavin monooxygenase (FMO) 2
IPR002257 Flavin monooxygenase (FMO) 5
IPR012143 Dimethylaniline monooxygenase, N-oxide-forming
IPR020946 Flavin monooxygenase-like
IPR023753 Pyridine nucleotide-disulphide oxidoreductase, FAD/NAD(P)-binding domain

PFAM

PF00743
PF07992

PRINTS

PR00370
PR01121
PR01122
PR01125

PIRSF

PIRSF000332

SMART

TIGRFAMs

Post-translational Modifications

Modification

Cross-References

SwissProt