InnateDB: Systems Biology of the Innate Immune Response

Mus musculus Protein: Vkorc1l1

Summary

InnateDB Protein

IDBP-202128.6

Last Modified

2014-10-13 [Report errors or provide feedback]

Gene Symbol

Vkorc1l1

Protein Name

vitamin K epoxide reductase complex, subunit 1-like 1

Synonyms

2310024K08Rik;

Species

Mus musculus

Ensembl Protein

ENSMUSP00000073601

InnateDB Gene

IDBG-202126 (Vkorc1l1)

Protein Structure

UniProt Annotation

Function

Involved in vitamin K metabolism. Can reduce inactive vitamin K 2,3-epoxide to active vitamin K (in vitro), and may contribute to vitamin K-mediated protection against oxidative stress. Plays a role in vitamin K-dependent gamma-carboxylation of Glu residues in target proteins. {ECO:0000269PubMed:23928358}.

Subcellular Localization

Endoplasmic reticulum membrane {ECO:0000269PubMed:23928358}; Multi-pass membrane protein {ECO:0000269PubMed:23928358}.

Disease Associations

Tissue Specificity

Detected in testis and lung. {ECO:0000269PubMed:23928358}.

Comments

Interactions

Number of Interactions

This gene and/or its encoded proteins are associated with 0 experimentally validated interaction(s) in this database.

Gene Ontology

Molecular Function

Accession	GO Term
GO:0047057	vitamin-K-epoxide reductase (warfarin-sensitive) activity
GO:0048038	quinone binding

Biological Process

GO:0017187	peptidyl-glutamic acid carboxylation
GO:0034599	cellular response to oxidative stress
GO:0042373	vitamin K metabolic process
GO:0055114	oxidation-reduction process